3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)
WHI-P180
CAS: 211555-08-7
Molecular Formula: C16H15N3O3
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference) - Names and Identifiers
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference) - Physico-chemical Properties
| Molecular Formula | C16H15N3O3 |
| Molar Mass | 297.31 |
| Density | 1.336±0.06 g/cm3(Predicted) |
| Boling Point | 476.5±40.0 °C(Predicted) |
| pKa | 9.58±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| MDL | MFCD02683970 |
| In vivo study | WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. |
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.363 ml | 16.817 ml | 33.635 ml |
| 5 mM | 0.673 ml | 3.363 ml | 6.727 ml |
| 10 mM | 0.336 ml | 1.682 ml | 3.363 ml |
| 5 mM | 0.067 ml | 0.336 ml | 0.673 ml |
Last Update：2024-01-02 23:10:35
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference) - Reference Information
| biological activity | WHI-P180 is an inhibitor of multiple kinases, and the IC50 values for RET (c-RET) and KDR are 4.5 nM and 66 nM respectively. |
| Target | Value |
| RET (Cell-free assay) | 4.5 nM |
| KDR (Cell-free assay) | 66 nM |
Last Update：2024-04-09 21:04:16
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Product Name: WHI-P180 Visit Supplier Webpage Request for quotationCAS: 211555-08-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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